Response of antioxidant enzymes to Cd and Pb exposure in water flea Daphnia magna: Differential metal and age - Specific patterns.
Identifieur interne : 000221 ( Main/Exploration ); précédent : 000220; suivant : 000222Response of antioxidant enzymes to Cd and Pb exposure in water flea Daphnia magna: Differential metal and age - Specific patterns.
Auteurs : Haeyeon Kim [Corée du Sud] ; Ji-Soo Kim [Corée du Sud] ; Pyoung-Joong Kim [Corée du Sud] ; Eun-Ji Won [Corée du Sud] ; Young-Mi Lee [Corée du Sud]Source :
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [ 1532-0456 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Biomarqueurs environnementaux (effets des médicaments et des substances chimiques), Cadmium (toxicité), Chlorure de cadmium (toxicité), Concentration osmolaire (MeSH), Daphnia (croissance et développement), Daphnia (effets des médicaments et des substances chimiques), Daphnia (métabolisme), Eau douce (MeSH), Espèces réactives de l'oxygène (métabolisme), Facteurs âges (MeSH), Glutathion (agonistes), Glutathion (antagonistes et inhibiteurs), Glutathion (métabolisme), Glutathione transferase (composition chimique), Glutathione transferase (métabolisme), Marqueurs biologiques (métabolisme), Nitrates (toxicité), Plomb (toxicité), Polluants chimiques de l'eau (toxicité), Protéines d'arthropode (agonistes), Protéines d'arthropode (métabolisme), Protéines du choc thermique HSP70 (agonistes), Protéines du choc thermique HSP70 (génétique), Protéines du choc thermique HSP70 (métabolisme), Protéines du choc thermique HSP90 (agonistes), Protéines du choc thermique HSP90 (génétique), Protéines du choc thermique HSP90 (métabolisme), Régulation de l'expression des gènes au cours du développement (effets des médicaments et des substances chimiques), Stress oxydatif (effets des médicaments et des substances chimiques), Superoxide dismutase (composition chimique), Superoxide dismutase (métabolisme), Tests de toxicité aigüe (MeSH).
- MESH :
- agonistes : Glutathion, Protéines d'arthropode, Protéines du choc thermique HSP70, Protéines du choc thermique HSP90.
- antagonistes et inhibiteurs : Glutathion.
- composition chimique : Glutathione transferase, Superoxide dismutase.
- croissance et développement : Daphnia.
- effets des médicaments et des substances chimiques : Biomarqueurs environnementaux, Daphnia, Régulation de l'expression des gènes au cours du développement, Stress oxydatif.
- génétique : Protéines du choc thermique HSP70, Protéines du choc thermique HSP90.
- métabolisme : Daphnia, Espèces réactives de l'oxygène, Glutathion, Glutathione transferase, Marqueurs biologiques, Protéines d'arthropode, Protéines du choc thermique HSP70, Protéines du choc thermique HSP90, Superoxide dismutase.
- toxicité : Cadmium, Chlorure de cadmium, Nitrates, Plomb, Polluants chimiques de l'eau.
- Animaux, Concentration osmolaire, Eau douce, Facteurs âges, Tests de toxicité aigüe.
English descriptors
- KwdEn :
- Age Factors (MeSH), Animals (MeSH), Arthropod Proteins (agonists), Arthropod Proteins (metabolism), Biomarkers (metabolism), Cadmium (toxicity), Cadmium Chloride (toxicity), Daphnia (drug effects), Daphnia (growth & development), Daphnia (metabolism), Environmental Biomarkers (drug effects), Fresh Water (MeSH), Gene Expression Regulation, Developmental (drug effects), Glutathione (agonists), Glutathione (antagonists & inhibitors), Glutathione (metabolism), Glutathione Transferase (chemistry), Glutathione Transferase (metabolism), HSP70 Heat-Shock Proteins (agonists), HSP70 Heat-Shock Proteins (genetics), HSP70 Heat-Shock Proteins (metabolism), HSP90 Heat-Shock Proteins (agonists), HSP90 Heat-Shock Proteins (genetics), HSP90 Heat-Shock Proteins (metabolism), Lead (toxicity), Nitrates (toxicity), Osmolar Concentration (MeSH), Oxidative Stress (drug effects), Reactive Oxygen Species (metabolism), Superoxide Dismutase (chemistry), Superoxide Dismutase (metabolism), Toxicity Tests, Acute (MeSH), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , agonists : Arthropod Proteins, Glutathione, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins.
- chemical , antagonists & inhibitors : Glutathione.
- chemical , chemistry : Glutathione Transferase, Superoxide Dismutase.
- chemical , drug effects : Environmental Biomarkers.
- chemical , genetics : HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins.
- chemical , metabolism : Arthropod Proteins, Biomarkers, Glutathione, Glutathione Transferase, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Reactive Oxygen Species, Superoxide Dismutase.
- chemical , toxicity : Cadmium, Cadmium Chloride, Lead, Nitrates, Water Pollutants, Chemical.
- drug effects : Daphnia, Gene Expression Regulation, Developmental, Oxidative Stress.
- growth & development : Daphnia.
- metabolism : Daphnia.
- Age Factors, Animals, Fresh Water, Osmolar Concentration, Toxicity Tests, Acute.
Abstract
To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined. The results showed that intracellular ROS level was not changed at 24 h, but reduced at 48 h. Levels of total GSH content were reduced by Cd, but highly induced by Pb. SOD and GST activities were stimulated 48 h after exposure to Cd and Pb. A significant modulation of oxidative stress marker genes was observed after exposure to each element with different expression patterns depending on the metal and developmental stages. In particular, the expression levels of GST-sigma, HSP70, and HSP90 genes were enhanced in Cd - and Pb - exposed neonates. These findings imply that oxidative stress markers appear to be actively involved in cellular protection against metal-induced oxidative stress in D. magna. This study would facilitate the understanding of the molecular response to Cd and Pb exposure in water fleas.
DOI: 10.1016/j.cbpc.2018.03.010
PubMed: 29625344
Affiliations:
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Heat-Shock Proteins (agonists)</term><term>HSP70 Heat-Shock Proteins (genetics)</term><term>HSP70 Heat-Shock Proteins (metabolism)</term><term>HSP90 Heat-Shock Proteins (agonists)</term><term>HSP90 Heat-Shock Proteins (genetics)</term><term>HSP90 Heat-Shock Proteins (metabolism)</term><term>Lead (toxicity)</term><term>Nitrates (toxicity)</term><term>Osmolar Concentration (MeSH)</term><term>Oxidative Stress (drug effects)</term><term>Reactive Oxygen Species (metabolism)</term><term>Superoxide Dismutase (chemistry)</term><term>Superoxide Dismutase (metabolism)</term><term>Toxicity Tests, Acute (MeSH)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Biomarqueurs environnementaux (effets des médicaments et des substances chimiques)</term><term>Cadmium (toxicité)</term><term>Chlorure de cadmium (toxicité)</term><term>Concentration osmolaire (MeSH)</term><term>Daphnia (croissance et développement)</term><term>Daphnia (effets des médicaments et des substances chimiques)</term><term>Daphnia (métabolisme)</term><term>Eau douce (MeSH)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Facteurs âges (MeSH)</term><term>Glutathion (agonistes)</term><term>Glutathion (antagonistes et inhibiteurs)</term><term>Glutathion (métabolisme)</term><term>Glutathione transferase (composition chimique)</term><term>Glutathione transferase (métabolisme)</term><term>Marqueurs biologiques (métabolisme)</term><term>Nitrates (toxicité)</term><term>Plomb (toxicité)</term><term>Polluants chimiques de l'eau (toxicité)</term><term>Protéines d'arthropode (agonistes)</term><term>Protéines d'arthropode (métabolisme)</term><term>Protéines du choc thermique HSP70 (agonistes)</term><term>Protéines du choc thermique HSP70 (génétique)</term><term>Protéines du choc thermique HSP70 (métabolisme)</term><term>Protéines du choc thermique HSP90 (agonistes)</term><term>Protéines du choc thermique HSP90 (génétique)</term><term>Protéines du choc thermique HSP90 (métabolisme)</term><term>Régulation de l'expression des gènes au cours du développement (effets des médicaments et des substances chimiques)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Superoxide dismutase (composition chimique)</term><term>Superoxide dismutase (métabolisme)</term><term>Tests de toxicité aigüe (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="agonists" xml:lang="en"><term>Arthropod Proteins</term><term>Glutathione</term><term>HSP70 Heat-Shock Proteins</term><term>HSP90 Heat-Shock Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Glutathione</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glutathione Transferase</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Environmental Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HSP70 Heat-Shock Proteins</term><term>HSP90 Heat-Shock Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Arthropod Proteins</term><term>Biomarkers</term><term>Glutathione</term><term>Glutathione Transferase</term><term>HSP70 Heat-Shock Proteins</term><term>HSP90 Heat-Shock Proteins</term><term>Reactive Oxygen Species</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium</term><term>Cadmium Chloride</term><term>Lead</term><term>Nitrates</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="agonistes" xml:lang="fr"><term>Glutathion</term><term>Protéines d'arthropode</term><term>Protéines du choc thermique HSP70</term><term>Protéines du choc thermique HSP90</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Glutathion</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glutathione transferase</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Daphnia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Daphnia</term><term>Gene Expression Regulation, Developmental</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Biomarqueurs environnementaux</term><term>Daphnia</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Daphnia</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines du choc thermique HSP70</term><term>Protéines du choc thermique HSP90</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Daphnia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Daphnia</term><term>Espèces réactives de l'oxygène</term><term>Glutathion</term><term>Glutathione transferase</term><term>Marqueurs biologiques</term><term>Protéines d'arthropode</term><term>Protéines du choc thermique HSP70</term><term>Protéines du choc thermique HSP90</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Cadmium</term><term>Chlorure de cadmium</term><term>Nitrates</term><term>Plomb</term><term>Polluants chimiques de l'eau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Fresh Water</term><term>Osmolar Concentration</term><term>Toxicity Tests, Acute</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Concentration osmolaire</term><term>Eau douce</term><term>Facteurs âges</term><term>Tests de toxicité aigüe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined. The results showed that intracellular ROS level was not changed at 24 h, but reduced at 48 h. Levels of total GSH content were reduced by Cd, but highly induced by Pb. SOD and GST activities were stimulated 48 h after exposure to Cd and Pb. A significant modulation of oxidative stress marker genes was observed after exposure to each element with different expression patterns depending on the metal and developmental stages. In particular, the expression levels of GST-sigma, HSP70, and HSP90 genes were enhanced in Cd - and Pb - exposed neonates. These findings imply that oxidative stress markers appear to be actively involved in cellular protection against metal-induced oxidative stress in D. magna. This study would facilitate the understanding of the molecular response to Cd and Pb exposure in water fleas.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29625344</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>07</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1532-0456</ISSN><JournalIssue CitedMedium="Internet"><Volume>209</Volume><PubDate><Year>2018</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Comparative biochemistry and physiology. Toxicology & pharmacology : CBP</Title><ISOAbbreviation>Comp Biochem Physiol C Toxicol Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Response of antioxidant enzymes to Cd and Pb exposure in water flea Daphnia magna: Differential metal and age - Specific patterns.</ArticleTitle><Pagination><MedlinePgn>28-36</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1532-0456(18)30042-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cbpc.2018.03.010</ELocationID><Abstract><AbstractText>To investigate oxidative stress responses to cadmium and lead, the freshwater water flea Daphnia magna was exposed to Cd and Pb for 48 h. Following treatment with sub-lethal concentrations, intracellular reactive oxygen species (ROS) levels, as well as modulation of multiple biomarker, such as superoxide dismutase (SOD) activity, glutathione (GSH) contents, glutathione S-transferase (GST) activity, antioxidant enzyme - coding genes (three GST isoforms, glutaredoxin [GRx], glutathione peroxidase [GPx], and thioredoxin [TRx]), and stress-response proteins (heat shock protein 70 [Hsp70] and Hsp90) were examined. The results showed that intracellular ROS level was not changed at 24 h, but reduced at 48 h. Levels of total GSH content were reduced by Cd, but highly induced by Pb. SOD and GST activities were stimulated 48 h after exposure to Cd and Pb. A significant modulation of oxidative stress marker genes was observed after exposure to each element with different expression patterns depending on the metal and developmental stages. In particular, the expression levels of GST-sigma, HSP70, and HSP90 genes were enhanced in Cd - and Pb - exposed neonates. These findings imply that oxidative stress markers appear to be actively involved in cellular protection against metal-induced oxidative stress in D. magna. This study would facilitate the understanding of the molecular response to Cd and Pb exposure in water fleas.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Haeyeon</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Life Science, College of Natural Sciences, Sangmyung University, Seoul 03016, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Ji-Soo</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Biosafety Research Team, Environmental Health Research Department, National Institute of Environmental Research, Kyungseo-Dong, Seo-gu, Incheon 22689, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Pyoung-Joong</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>South Sea Fisheries Research Institute, National Institute of Fisheries Science, Yeosu, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Won</LastName><ForeName>Eun-Ji</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Marine Science and Convergent Technology, Hanyang University, Ansan 15588, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young-Mi</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Department of Life Science, College of Natural Sciences, Sangmyung University, Seoul 03016, Republic of Korea. Electronic address: ymlee70@smu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Comp Biochem Physiol C Toxicol Pharmacol</MedlineTA><NlmUniqueID>100959500</NlmUniqueID><ISSNLinking>1532-0456</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D060829">Arthropod Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000074062">Environmental Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018840">HSP70 Heat-Shock Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018841">HSP90 Heat-Shock Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009566">Nitrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>00BH33GNGH</RegistryNumber><NameOfSubstance UI="D002104">Cadmium</NameOfSubstance></Chemical><Chemical><RegistryNumber>2P299V784P</RegistryNumber><NameOfSubstance UI="D007854">Lead</NameOfSubstance></Chemical><Chemical><RegistryNumber>6E5P1699FI</RegistryNumber><NameOfSubstance UI="C017461">lead nitrate</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber><NameOfSubstance UI="D005978">Glutathione</NameOfSubstance></Chemical><Chemical><RegistryNumber>J6K4F9V3BA</RegistryNumber><NameOfSubstance UI="D019256">Cadmium Chloride</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060829" MajorTopicYN="N">Arthropod Proteins</DescriptorName><QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002104" MajorTopicYN="N">Cadmium</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019256" MajorTopicYN="N">Cadmium Chloride</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003621" MajorTopicYN="N">Daphnia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000074062" MajorTopicYN="N">Environmental Biomarkers</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005618" MajorTopicYN="N">Fresh Water</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName><QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018840" MajorTopicYN="N">HSP70 Heat-Shock Proteins</DescriptorName><QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018841" MajorTopicYN="N">HSP90 Heat-Shock Proteins</DescriptorName><QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007854" MajorTopicYN="N">Lead</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009566" MajorTopicYN="N">Nitrates</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009994" MajorTopicYN="N">Osmolar Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023382" MajorTopicYN="N">Toxicity Tests, Acute</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant enzymes</Keyword><Keyword MajorTopicYN="N">Cadmium</Keyword><Keyword MajorTopicYN="N">Daphnia magna</Keyword><Keyword MajorTopicYN="N">Lead</Keyword><Keyword MajorTopicYN="N">Multiple biomarkers</Keyword><Keyword MajorTopicYN="N">Water flea</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29625344</ArticleId><ArticleId IdType="pii">S1532-0456(18)30042-5</ArticleId><ArticleId IdType="doi">10.1016/j.cbpc.2018.03.010</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Haeyeon" sort="Kim, Haeyeon" uniqKey="Kim H" first="Haeyeon" last="Kim">Haeyeon Kim</name></region><name sortKey="Kim, Ji Soo" sort="Kim, Ji Soo" uniqKey="Kim J" first="Ji-Soo" last="Kim">Ji-Soo Kim</name><name sortKey="Kim, Pyoung Joong" sort="Kim, Pyoung Joong" uniqKey="Kim P" first="Pyoung-Joong" last="Kim">Pyoung-Joong Kim</name><name sortKey="Lee, Young Mi" sort="Lee, Young Mi" uniqKey="Lee Y" first="Young-Mi" last="Lee">Young-Mi Lee</name><name sortKey="Won, Eun Ji" sort="Won, Eun Ji" uniqKey="Won E" first="Eun-Ji" last="Won">Eun-Ji Won</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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